`G0483` Drug test def 22+ classes

What G0483 is

Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/ms (any type, single or tandem and excluding immunoassays (e.g., ia, eia, elisa, emit, fpia) and enzymatic methods (e.g., alcohol dehydrogenase)), (2) stable isotope or other universally recognized internal standards in all samples (e.g., to control for matrix effects, interferences and variations in signal strength), and (3) method or drug-specific calibration and matrix-matched quality control material (e.g., to control for instrument variations and mass spectral drift); qualitative or quantitative, all sources, includes specimen validity testing, per day; 22 or more drug class(es), including metabolite(s) if performed

HCPCS Level II long description, CMS October 2026 file. See the G codes page for the full section.

Medicare payment for G0483 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

Medically Unlikely Edit (MUE)

Medicare caps G0483 at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: Code Descriptor / CPT Instruction. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with G0483? These codes are bundled into it

G0483 is a Column 1 code in 95 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 code	Short description	Modifier indicator
`0011U`		0 - no modifier bypass	Check pair
`0051U`		0 - no modifier bypass	Check pair
`0054U`		0 - no modifier bypass	Check pair
`0093U`		0 - no modifier bypass	Check pair
`0110U`		0 - no modifier bypass	Check pair
`0116U`		0 - no modifier bypass	Check pair
`0119U`		1 - modifier may bypass	Check pair
`0251U`		1 - modifier may bypass	Check pair
`0517U`		1 - modifier may bypass	Check pair
`0518U`		1 - modifier may bypass	Check pair
`0519U`		1 - modifier may bypass	Check pair
`0520U`		1 - modifier may bypass	Check pair
`80320`	Drug screen quantalcohols	0 - no modifier bypass	Check pair
`80321`	Alcohols biomarkers 1or 2	0 - no modifier bypass	Check pair
`80322`	Alcohols biomarkers 3/more	0 - no modifier bypass	Check pair
`80323`	Alkaloids nos	0 - no modifier bypass	Check pair
`80324`	Drug screen amphetamines 1/2	0 - no modifier bypass	Check pair
`80325`	Amphetamines 3or 4	0 - no modifier bypass	Check pair
`80326`	Amphetamines 5 or more	0 - no modifier bypass	Check pair
`80327`	Anabolic steroid 1 or 2	0 - no modifier bypass	Check pair
`80328`	Anabolic steroid 3 or more	0 - no modifier bypass	Check pair
`80329`	Analgesics non-opioid 1 or 2	0 - no modifier bypass	Check pair
`80330`	Analgesics non-opioid 3-5	0 - no modifier bypass	Check pair
`80331`	Analgesics non-opioid 6/more	0 - no modifier bypass	Check pair
`80332`	Antidepressants class 1 or 2	0 - no modifier bypass	Check pair
`80333`	Antidepressants class 3-5	0 - no modifier bypass	Check pair
`80334`	Antidepressants class 6/more	0 - no modifier bypass	Check pair
`80335`	Antidepressant tricyclic 1/2	0 - no modifier bypass	Check pair
`80336`	Antidepressant tricyclic 3-5	0 - no modifier bypass	Check pair
`80337`	Tricyclic & cyclicals 6/more	0 - no modifier bypass	Check pair

Showing 30 of 95 column 2 codes. Use the pair checker for any specific combination.

G0483 is bundled into these codes

G0483 appears as a Column 2 code in 4 active edits. Reported with one of these Column 1 codes on the same date of service, G0483 is the code that denies.

Column 1 code	Short description	Modifier indicator
`0007U`		0	Check pair
`0082U`		0	Check pair
`0227U`		0	Check pair
`0328U`		0	Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.