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96425 Chemotherapy infusion method

What 96425 is

CMS fee schedule short descriptor: Chemotherapy infusion method.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 96425 (CY2026)

Work RVUPractice expense RVUMalpractice RVUTotalMedicare rate
Non-facility (office)0.174.930.115.21$174.02
Facility (hospital, ASC)0.174.930.115.21$174.02

National rates: total RVUs x the CY2026 conversion factor of 33.4009 (non-QP), before geographic adjustment. Actual Medicare payment is 80% of the rate shown after the deductible; the patient or secondary payer owes the 20% coinsurance.


Status: Active - payable under the Physician Fee Schedule. Global period: Global concept does not apply.

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Medically Unlikely Edit (MUE)

Medicare caps 96425 at 1 unit per date of service for practitioner claims (MAI 3 - date of service edit (clinical): units above the MUE may pay with documentation on appeal), rationale: Nature of Service/Procedure. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 96425? These codes are bundled into it

96425 is a Column 1 code in 43 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
0708TId ca immntx prep & 1st njx1 - modifier may bypassCheck pair
0709TId ca immntx each addl njx1 - modifier may bypassCheck pair
11900Inject skin lesions </w 71 - modifier may bypassCheck pair
11901Inject skin lesions >71 - modifier may bypassCheck pair
36500Insertion of catheter vein1 - modifier may bypassCheck pair
36591Draw blood off venous device0 - no modifier bypassCheck pair
36592Collect blood from picc0 - no modifier bypassCheck pair
64450Njx aa&/strd other pn/branch1 - modifier may bypassCheck pair
64454Njx aa&/strd gnclr nrv brnch1 - modifier may bypassCheck pair
64473Lwr xtr fscl pln blk uni njx1 - modifier may bypassCheck pair
64474Lwr xtr fscl pln blk uni nfs1 - modifier may bypassCheck pair
64486Tap block unil by injection1 - modifier may bypassCheck pair
64487Tap block uni by infusion1 - modifier may bypassCheck pair
64488Tap block bi injection1 - modifier may bypassCheck pair
64489Tap block bi by infusion1 - modifier may bypassCheck pair
75893Venous sampling by catheter1 - modifier may bypassCheck pair
96360Hydration iv infusion init1 - modifier may bypassCheck pair
96365Ther/proph/diag iv inf init1 - modifier may bypassCheck pair
96372Ther/proph/diag inj sc/im1 - modifier may bypassCheck pair
96374Ther/proph/diag inj iv push1 - modifier may bypassCheck pair
96375Tx/pro/dx inj new drug addon1 - modifier may bypassCheck pair
96376Tx/pro/dx inj same drug adon1 - modifier may bypassCheck pair
96377Applicaton on-body injector1 - modifier may bypassCheck pair
96521Refill/maint portable pump0 - no modifier bypassCheck pair
96522Refill/maint pump/resvr syst0 - no modifier bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair
99202Office o/p new sf 15 min1 - modifier may bypassCheck pair
99203Office o/p new low 30 min1 - modifier may bypassCheck pair
99204Office o/p new mod 45 min1 - modifier may bypassCheck pair
99205Office o/p new hi 60 min1 - modifier may bypassCheck pair

Showing 30 of 43 column 2 codes. Use the pair checker for any specific combination.

96425 is bundled into these codes

96425 appears as a Column 2 code in 69 active edits. Reported with one of these Column 1 codes on the same date of service, 96425 is the code that denies.

Column 1 codeShort descriptionModifier indicator
36823Insertion of cannula(s)1Check pair
61650Evasc prlng admn rx agnt 1st1Check pair
61651Evasc prlng admn rx agnt add1Check pair
77750Infuse radioactive materials0Check pair
992211st hosp ip/obs sf/low 401Check pair
992221st hosp ip/obs moderate 551Check pair
992231st hosp ip/obs high 751Check pair
99231Sbsq hosp ip/obs sf/low 250Check pair
99232Sbsq hosp ip/obs moderate 350Check pair
99233Sbsq hosp ip/obs high 500Check pair
99234Hosp ip/obs sm dt sf/low 451Check pair
99235Hosp ip/obs same date mod 701Check pair
99236Hosp ip/obs same date hi 851Check pair
99238Hosp ip/obs dschrg mgmt 30/<1Check pair
99239Hosp ip/obs dschrg mgmt >301Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.