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91321 Sarscov2 vac 25 mcg/.25ml im

What 91321 is

CMS fee schedule short descriptor: Sarscov2 vac 25 mcg/.25ml im.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 91321 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

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Medically Unlikely Edit (MUE)

Medicare caps 91321 at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: Code Descriptor / CPT Instruction. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 91321? These codes are bundled into it

91321 is a Column 1 code in 6 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
36591Draw blood off venous device0 - no modifier bypassCheck pair
36592Collect blood from picc0 - no modifier bypassCheck pair
91318Sarscov2 vac 3mcg trs-suc im0 - no modifier bypassCheck pair
91319Sarscv2 vac 10mcg trs-suc im0 - no modifier bypassCheck pair
91320Sarscv2 vac 30mcg trs-suc im0 - no modifier bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair

91321 is bundled into these codes

91321 appears as a Column 2 code in 1 active edits. Reported with one of these Column 1 codes on the same date of service, 91321 is the code that denies.

Column 1 codeShort descriptionModifier indicator
91322Sarscov2 vac 50 mcg/0.5ml im0Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.