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88381 Microdissection manual

What 88381 is

CMS fee schedule short descriptor: Microdissection manual.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 88381 (CY2026)

Work RVUPractice expense RVUMalpractice RVUTotalMedicare rate
Non-facility (office)0.525.050.055.62$187.71
Facility (hospital, ASC)0.525.050.055.62$187.71

National rates: total RVUs x the CY2026 conversion factor of 33.4009 (non-QP), before geographic adjustment. Actual Medicare payment is 80% of the rate shown after the deductible; the patient or secondary payer owes the 20% coinsurance.


Status: Active - payable under the Physician Fee Schedule. Global period: Global concept does not apply.

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Medically Unlikely Edit (MUE)

Medicare caps 88381 at 1 unit per date of service for practitioner claims (MAI 3 - date of service edit (clinical): units above the MUE may pay with documentation on appeal), rationale: Clinical: CMS Workgroup. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 88381? These codes are bundled into it

88381 is a Column 1 code in 6 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
88355M/phmtrc alys skeletal musc1 - modifier may bypassCheck pair
88358Analysis tumor1 - modifier may bypassCheck pair
88360Tumor immunohistochem/manual1 - modifier may bypassCheck pair
88361Tumor immunohistochem/comput1 - modifier may bypassCheck pair
88363Xm archive tissue molec anal1 - modifier may bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair

88381 is bundled into these codes

88381 appears as a Column 2 code in 11 active edits. Reported with one of these Column 1 codes on the same date of service, 88381 is the code that denies.

Column 1 codeShort descriptionModifier indicator
0009U1Check pair
0249U1Check pair
88120Cytp urne 3-5 probes ea spec1Check pair
88121Cytp urine 3-5 probes cmptr1Check pair
88356Analysis nerve1Check pair
88362Nerve teasing preparations1Check pair
88367Insitu hybridization auto1Check pair
88368Insitu hybridization manual1Check pair
88374M/phmtrc alys ishquant/semiq1Check pair
88377M/phmtrc alys ishquant/semiq1Check pair
88380Microdissection laser1Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.