88381 Microdissection manual
What 88381 is
CMS fee schedule short descriptor: Microdissection manual.
Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.
Medicare payment for 88381 (CY2026)
| Work RVU | Practice expense RVU | Malpractice RVU | Total | Medicare rate | |
|---|---|---|---|---|---|
| Non-facility (office) | 0.52 | 5.05 | 0.05 | 5.62 | $187.71 |
| Facility (hospital, ASC) | 0.52 | 5.05 | 0.05 | 5.62 | $187.71 |
National rates: total RVUs x the CY2026 conversion factor of 33.4009 (non-QP), before geographic adjustment. Actual Medicare payment is 80% of the rate shown after the deductible; the patient or secondary payer owes the 20% coinsurance.
Status: Active - payable under the Physician Fee Schedule. Global period: Global concept does not apply.
Medically Unlikely Edit (MUE)
Medicare caps 88381 at 1 unit per date of service for practitioner claims (MAI 3 - date of service edit (clinical): units above the MUE may pay with documentation on appeal), rationale: Clinical: CMS Workgroup. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.
Billed with 88381? These codes are bundled into it
88381 is a Column 1 code in 6 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.
| Column 2 code | Short description | Modifier indicator | |
|---|---|---|---|
88355 | M/phmtrc alys skeletal musc | 1 - modifier may bypass | Check pair |
88358 | Analysis tumor | 1 - modifier may bypass | Check pair |
88360 | Tumor immunohistochem/manual | 1 - modifier may bypass | Check pair |
88361 | Tumor immunohistochem/comput | 1 - modifier may bypass | Check pair |
88363 | Xm archive tissue molec anal | 1 - modifier may bypass | Check pair |
96523 | Irrig drug delivery device | 0 - no modifier bypass | Check pair |
88381 is bundled into these codes
88381 appears as a Column 2 code in 11 active edits. Reported with one of these Column 1 codes on the same date of service, 88381 is the code that denies.
| Column 1 code | Short description | Modifier indicator | |
|---|---|---|---|
0009U | 1 | Check pair | |
0249U | 1 | Check pair | |
88120 | Cytp urne 3-5 probes ea spec | 1 | Check pair |
88121 | Cytp urine 3-5 probes cmptr | 1 | Check pair |
88356 | Analysis nerve | 1 | Check pair |
88362 | Nerve teasing preparations | 1 | Check pair |
88367 | Insitu hybridization auto | 1 | Check pair |
88368 | Insitu hybridization manual | 1 | Check pair |
88374 | M/phmtrc alys ishquant/semiq | 1 | Check pair |
88377 | M/phmtrc alys ishquant/semiq | 1 | Check pair |
88380 | Microdissection laser | 1 | Check pair |
Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.