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88374 M/phmtrc alys ishquant/semiq

What 88374 is

CMS fee schedule short descriptor: M/phmtrc alys ishquant/semiq.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 88374 (CY2026)

Work RVUPractice expense RVUMalpractice RVUTotalMedicare rate
Non-facility (office)0.917.040.027.97$266.21
Facility (hospital, ASC)0.917.040.027.97$266.21

National rates: total RVUs x the CY2026 conversion factor of 33.4009 (non-QP), before geographic adjustment. Actual Medicare payment is 80% of the rate shown after the deductible; the patient or secondary payer owes the 20% coinsurance.


Status: Active - payable under the Physician Fee Schedule. Global period: Global concept does not apply.

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Medically Unlikely Edit (MUE)

Medicare caps 88374 at 5 units per date of service for practitioner claims (MAI 3 - date of service edit (clinical): units above the MUE may pay with documentation on appeal), rationale: Clinical: Data. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 88374? These codes are bundled into it

88374 is a Column 1 code in 16 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
80503Path clin consltj sf 5-201 - modifier may bypassCheck pair
80504Path clin consltj mod 21-401 - modifier may bypassCheck pair
80505Path clin consltj high 41-601 - modifier may bypassCheck pair
80506Path clin consltj prolng svc1 - modifier may bypassCheck pair
88271Cytogenetics dna probe1 - modifier may bypassCheck pair
88272Cytogenetics 3-51 - modifier may bypassCheck pair
88273Cytogenetics 10-301 - modifier may bypassCheck pair
88274Cytogenetics 25-991 - modifier may bypassCheck pair
88275Cytogenetics 100-3001 - modifier may bypassCheck pair
88346Imfluor 1st 1antb stain px1 - modifier may bypassCheck pair
88358Analysis tumor1 - modifier may bypassCheck pair
88365Insitu hybridization (fish)1 - modifier may bypassCheck pair
88368Insitu hybridization manual1 - modifier may bypassCheck pair
88380Microdissection laser1 - modifier may bypassCheck pair
88381Microdissection manual1 - modifier may bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair

88374 is bundled into these codes

88374 appears as a Column 2 code in 469 active edits. Reported with one of these Column 1 codes on the same date of service, 88374 is the code that denies.

Column 1 codeShort descriptionModifier indicator
0001U1Check pair
0004M1Check pair
0005U1Check pair
0006M1Check pair
0007M1Check pair
0007U1Check pair
0008U1Check pair
0009U1Check pair
0010U1Check pair
0011M1Check pair
0012M1Check pair
0013M1Check pair
0016M1Check pair
0016U1Check pair
0017U1Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.