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81539 Oncology prostate prob score

What 81539 is

CMS fee schedule short descriptor: Oncology prostate prob score.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 81539 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

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Medically Unlikely Edit (MUE)

Medicare caps 81539 at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: CMS Policy. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 81539? These codes are bundled into it

81539 is a Column 1 code in 19 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
0011M0 - no modifier bypassCheck pair
0021U0 - no modifier bypassCheck pair
0133U0 - no modifier bypassCheck pair
0317U1 - modifier may bypassCheck pair
0403U0 - no modifier bypassCheck pair
0433U0 - no modifier bypassCheck pair
0512U0 - no modifier bypassCheck pair
0513U1 - modifier may bypassCheck pair
80503Path clin consltj sf 5-201 - modifier may bypassCheck pair
80504Path clin consltj mod 21-401 - modifier may bypassCheck pair
80505Path clin consltj high 41-601 - modifier may bypassCheck pair
80506Path clin consltj prolng svc1 - modifier may bypassCheck pair
81551Onc prostate 3 genes0 - no modifier bypassCheck pair
84152Assay of psa complexed0 - no modifier bypassCheck pair
84153Assay of psa total0 - no modifier bypassCheck pair
84154Assay of psa free0 - no modifier bypassCheck pair
88291Cyto/molecular report1 - modifier may bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair
G0452Molecular pathology interpr1 - modifier may bypassCheck pair

81539 is bundled into these codes

81539 appears as a Column 2 code in 10 active edits. Reported with one of these Column 1 codes on the same date of service, 81539 is the code that denies.

Column 1 codeShort descriptionModifier indicator
0047U0Check pair
0228U0Check pair
0339U0Check pair
0343U0Check pair
0359U0Check pair
0424U0Check pair
0475U0Check pair
0495U0Check pair
0497U0Check pair
81541Onc prostate mrna 46 genes0Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.