81539 Oncology prostate prob score
What 81539 is
CMS fee schedule short descriptor: Oncology prostate prob score.
Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.
Medicare payment for 81539 (CY2026)
This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.
Medically Unlikely Edit (MUE)
Medicare caps 81539 at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: CMS Policy. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.
Billed with 81539? These codes are bundled into it
81539 is a Column 1 code in 19 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.
| Column 2 code | Short description | Modifier indicator | |
|---|---|---|---|
0011M | 0 - no modifier bypass | Check pair | |
0021U | 0 - no modifier bypass | Check pair | |
0133U | 0 - no modifier bypass | Check pair | |
0317U | 1 - modifier may bypass | Check pair | |
0403U | 0 - no modifier bypass | Check pair | |
0433U | 0 - no modifier bypass | Check pair | |
0512U | 0 - no modifier bypass | Check pair | |
0513U | 1 - modifier may bypass | Check pair | |
80503 | Path clin consltj sf 5-20 | 1 - modifier may bypass | Check pair |
80504 | Path clin consltj mod 21-40 | 1 - modifier may bypass | Check pair |
80505 | Path clin consltj high 41-60 | 1 - modifier may bypass | Check pair |
80506 | Path clin consltj prolng svc | 1 - modifier may bypass | Check pair |
81551 | Onc prostate 3 genes | 0 - no modifier bypass | Check pair |
84152 | Assay of psa complexed | 0 - no modifier bypass | Check pair |
84153 | Assay of psa total | 0 - no modifier bypass | Check pair |
84154 | Assay of psa free | 0 - no modifier bypass | Check pair |
88291 | Cyto/molecular report | 1 - modifier may bypass | Check pair |
96523 | Irrig drug delivery device | 0 - no modifier bypass | Check pair |
G0452 | Molecular pathology interpr | 1 - modifier may bypass | Check pair |
81539 is bundled into these codes
81539 appears as a Column 2 code in 10 active edits. Reported with one of these Column 1 codes on the same date of service, 81539 is the code that denies.
| Column 1 code | Short description | Modifier indicator | |
|---|---|---|---|
0047U | 0 | Check pair | |
0228U | 0 | Check pair | |
0339U | 0 | Check pair | |
0343U | 0 | Check pair | |
0359U | 0 | Check pair | |
0424U | 0 | Check pair | |
0475U | 0 | Check pair | |
0495U | 0 | Check pair | |
0497U | 0 | Check pair | |
81541 | Onc prostate mrna 46 genes | 0 | Check pair |
Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.