81426 Genome sequence analysis

What 81426 is

CMS fee schedule short descriptor: Genome sequence analysis.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 81426 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

Medically Unlikely Edit (MUE)

Medicare caps 81426 at 2 units per date of service for practitioner claims (MAI 3 - date of service edit (clinical): units above the MUE may pay with documentation on appeal), rationale: Nature of Analyte. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 81426? These codes are bundled into it

81426 is a Column 1 code in 308 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Showing 30 of 308 column 2 codes. Use the pair checker for any specific combination.

81426 is bundled into these codes

81426 appears as a Column 2 code in 40 active edits. Reported with one of these Column 1 codes on the same date of service, 81426 is the code that denies.

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.