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81349 Cytog alys chrml abnr lw-ps

What 81349 is

CMS fee schedule short descriptor: Cytog alys chrml abnr lw-ps.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 81349 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

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Medically Unlikely Edit (MUE)

Medicare caps 81349 at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: Code Descriptor / CPT Instruction. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 81349? These codes are bundled into it

81349 is a Column 1 code in 166 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
0169U1 - modifier may bypassCheck pair
0171U1 - modifier may bypassCheck pair
0177U1 - modifier may bypassCheck pair
0202U1 - modifier may bypassCheck pair
0212U0 - no modifier bypassCheck pair
0213U0 - no modifier bypassCheck pair
0235U1 - modifier may bypassCheck pair
0330U1 - modifier may bypassCheck pair
0331U1 - modifier may bypassCheck pair
0336U0 - no modifier bypassCheck pair
0340U1 - modifier may bypassCheck pair
0405U1 - modifier may bypassCheck pair
0417U0 - no modifier bypassCheck pair
0425U0 - no modifier bypassCheck pair
0426U1 - modifier may bypassCheck pair
0429U1 - modifier may bypassCheck pair
0469U1 - modifier may bypassCheck pair
0489U1 - modifier may bypassCheck pair
81168Ccnd1/igh translocation alys1 - modifier may bypassCheck pair
81410Aortic dysfunction/dilation1 - modifier may bypassCheck pair
81411Aortic dysfunction/dilation1 - modifier may bypassCheck pair
81412Ashkenazi jewish assoc dis1 - modifier may bypassCheck pair
81415Exome sequence analysis1 - modifier may bypassCheck pair
81416Exome sequence analysis1 - modifier may bypassCheck pair
81417Exome re-evaluation1 - modifier may bypassCheck pair
81420Fetal chrmoml aneuploidy1 - modifier may bypassCheck pair
81425Genome sequence analysis1 - modifier may bypassCheck pair
81426Genome sequence analysis1 - modifier may bypassCheck pair
81427Genome re-evaluation1 - modifier may bypassCheck pair
81430Hearing loss sequence analys1 - modifier may bypassCheck pair

Showing 30 of 166 column 2 codes. Use the pair checker for any specific combination.

81349 is bundled into these codes

81349 appears as a Column 2 code in 12 active edits. Reported with one of these Column 1 codes on the same date of service, 81349 is the code that denies.

Column 1 codeShort descriptionModifier indicator
0010U1Check pair
0016M1Check pair
0079U0Check pair
0318U0Check pair
0413U1Check pair
0449U1Check pair
0454U1Check pair
0474U1Check pair
81195Cytog genom-wid alys hem mal1Check pair
81228Cytog alys chrml abnr cgh0Check pair
81229Cytog alys chrml abnr snpcgh0Check pair
81546Onc thyr mrna 10,196 gen alg1Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.