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81216 Brca2 gene full seq alys

What 81216 is

CMS fee schedule short descriptor: Brca2 gene full seq alys.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 81216 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

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Medically Unlikely Edit (MUE)

Medicare caps 81216 at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: Code Descriptor / CPT Instruction. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 81216? These codes are bundled into it

81216 is a Column 1 code in 138 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
0009U1 - modifier may bypassCheck pair
0068U1 - modifier may bypassCheck pair
0086U1 - modifier may bypassCheck pair
0112U1 - modifier may bypassCheck pair
0115U1 - modifier may bypassCheck pair
0140U1 - modifier may bypassCheck pair
0141U1 - modifier may bypassCheck pair
0142U1 - modifier may bypassCheck pair
0202U1 - modifier may bypassCheck pair
0321U1 - modifier may bypassCheck pair
0330U1 - modifier may bypassCheck pair
0429U1 - modifier may bypassCheck pair
80503Path clin consltj sf 5-201 - modifier may bypassCheck pair
80504Path clin consltj mod 21-401 - modifier may bypassCheck pair
80505Path clin consltj high 41-601 - modifier may bypassCheck pair
80506Path clin consltj prolng svc1 - modifier may bypassCheck pair
81217Brca2 gene known famil vrnt0 - no modifier bypassCheck pair
81513Nfct ds bv rna vag flu alg1 - modifier may bypassCheck pair
84311Spectrophotometry1 - modifier may bypassCheck pair
87140Culture type immunofluoresc1 - modifier may bypassCheck pair
87143Culture typing glc/hplc1 - modifier may bypassCheck pair
87147Culture type immunologic1 - modifier may bypassCheck pair
87149Dna/rna direct probe1 - modifier may bypassCheck pair
87150Dna/rna amplified probe1 - modifier may bypassCheck pair
87152Culture type pulse field gel1 - modifier may bypassCheck pair
87153Dna/rna sequencing1 - modifier may bypassCheck pair
87154Cul typ id bld pthgn 6+ trgt1 - modifier may bypassCheck pair
87158Culture typing added method1 - modifier may bypassCheck pair
87468Anaplsma phgcytophlm amp prb1 - modifier may bypassCheck pair
87469Babesia microti amp prb1 - modifier may bypassCheck pair

Showing 30 of 138 column 2 codes. Use the pair checker for any specific combination.

81216 is bundled into these codes

81216 appears as a Column 2 code in 189 active edits. Reported with one of these Column 1 codes on the same date of service, 81216 is the code that denies.

Column 1 codeShort descriptionModifier indicator
0001U1Check pair
0004M1Check pair
0005U1Check pair
0006M1Check pair
0007M1Check pair
0008U1Check pair
0010U1Check pair
0011M1Check pair
0012M1Check pair
0013M1Check pair
0016M1Check pair
0018U1Check pair
0019U1Check pair
0022U1Check pair
0023U1Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.