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80053 Comprehen metabolic panel

What 80053 is

CMS fee schedule short descriptor: Comprehen metabolic panel.

Full CPT long descriptions are licensed by the American Medical Association and are not published on this site; the short descriptor above is the one CMS prints in its own fee schedule file. See About CPT.

Medicare payment for 80053 (CY2026)

This code has no Physician Fee Schedule rate: Statutory exclusion - not payable under the Physician Fee Schedule. It may be paid under a different fee schedule (clinical laboratory, DMEPOS, anesthesia) or not paid at all - check the relevant CMS schedule.

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Medically Unlikely Edit (MUE)

Medicare caps 80053 at 1 unit per date of service for practitioner claims (MAI 3 - date of service edit (clinical): units above the MUE may pay with documentation on appeal), rationale: CMS Policy. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 80053? These codes are bundled into it

80053 is a Column 1 code in 20 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
80047Basic metablc pnl ionized ca1 - modifier may bypassCheck pair
80048Basic metabolic pnl total ca0 - no modifier bypassCheck pair
80051Electrolyte panel1 - modifier may bypassCheck pair
80069Renal function panel0 - no modifier bypassCheck pair
80076Hepatic function panel0 - no modifier bypassCheck pair
82040Assay of serum albumin1 - modifier may bypassCheck pair
82247Bilirubin total1 - modifier may bypassCheck pair
82310Assay of calcium1 - modifier may bypassCheck pair
82374Assay blood carbon dioxide1 - modifier may bypassCheck pair
82435Assay of blood chloride1 - modifier may bypassCheck pair
82565Assay of creatinine1 - modifier may bypassCheck pair
82947Assay glucose blood quant1 - modifier may bypassCheck pair
84075Assay alkaline phosphatase1 - modifier may bypassCheck pair
84132Assay of serum potassium1 - modifier may bypassCheck pair
84155Assay of protein serum1 - modifier may bypassCheck pair
84295Assay of serum sodium1 - modifier may bypassCheck pair
84450Transferase (ast) (sgot)1 - modifier may bypassCheck pair
84460Alanine amino (alt) (sgpt)1 - modifier may bypassCheck pair
84520Assay of urea nitrogen1 - modifier may bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair

80053 is bundled into these codes

80053 appears as a Column 2 code in 4 active edits. Reported with one of these Column 1 codes on the same date of service, 80053 is the code that denies.

Column 1 codeShort descriptionModifier indicator
0002M0Check pair
0003M0Check pair
0166U0Check pair
0344U0Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.