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0453U

What 0453U is

This code appears in the Medicare NCCI edit tables. It has no RVUs in the CY2026 Physician Fee Schedule file.

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Medically Unlikely Edit (MUE)

Medicare caps 0453U at 1 unit per date of service for practitioner claims (MAI 2 - date of service edit (absolute): units above the MUE never pay), rationale: Code Descriptor / CPT Instruction. Units above the cap are denied unless the edit's adjudication rules allow an appeal with documentation.

Billed with 0453U? These codes are bundled into it

0453U is a Column 1 code in 23 active NCCI PTP edits. When one of these Column 2 codes is reported on the same date of service, it is denied as bundled - unless the edit's modifier indicator is 1 and documentation supports a distinct service with an NCCI-associated modifier.

Column 2 codeShort descriptionModifier indicator
0501U0 - no modifier bypassCheck pair
36591Draw blood off venous device0 - no modifier bypassCheck pair
36592Collect blood from picc0 - no modifier bypassCheck pair
80503Path clin consltj sf 5-201 - modifier may bypassCheck pair
80504Path clin consltj mod 21-401 - modifier may bypassCheck pair
80505Path clin consltj high 41-601 - modifier may bypassCheck pair
81327Sept9 gen prmtr mthyltn alys0 - no modifier bypassCheck pair
84311Spectrophotometry1 - modifier may bypassCheck pair
88271Cytogenetics dna probe1 - modifier may bypassCheck pair
88272Cytogenetics 3-51 - modifier may bypassCheck pair
88273Cytogenetics 10-301 - modifier may bypassCheck pair
88274Cytogenetics 25-991 - modifier may bypassCheck pair
88275Cytogenetics 100-3001 - modifier may bypassCheck pair
88291Cyto/molecular report1 - modifier may bypassCheck pair
88365Insitu hybridization (fish)1 - modifier may bypassCheck pair
88366Insitu hybridization (fish)1 - modifier may bypassCheck pair
88367Insitu hybridization auto1 - modifier may bypassCheck pair
88368Insitu hybridization manual1 - modifier may bypassCheck pair
88374M/phmtrc alys ishquant/semiq1 - modifier may bypassCheck pair
88377M/phmtrc alys ishquant/semiq1 - modifier may bypassCheck pair
96523Irrig drug delivery device0 - no modifier bypassCheck pair
G0327Colon ca scrn;bld-bsd biomrk1 - modifier may bypassCheck pair
G0452Molecular pathology interpr1 - modifier may bypassCheck pair

0453U is bundled into these codes

0453U appears as a Column 2 code in 45 active edits. Reported with one of these Column 1 codes on the same date of service, 0453U is the code that denies.

Column 1 codeShort descriptionModifier indicator
0019U1Check pair
0036U1Check pair
0037U1Check pair
0050U1Check pair
0069U1Check pair
0101U1Check pair
0174U1Check pair
0211U1Check pair
0229U0Check pair
0285U1Check pair
0306U1Check pair
0307U1Check pair
0329U1Check pair
0340U1Check pair
0421U0Check pair

Data: CMS CY2026 Physician Fee Schedule RVU file (October release, RVU26D) and Medicare NCCI PTP practitioner edits v32.3 (2026 Q4). Verify against the official files before billing or contracting decisions.